Which agent would be used to counteract a severe reaction occurring with the use of neostigmine?

Neostigmine act as Cholinesterase inhibitors. it inhibits enzyme Cholinesterase as a competitive reversible antagonists.

This is an enzyme which normally breakdown neurotransmitter acetycholine at the neuromuscular junction (cholinergic synapses). and therefore the termination of synaptic neurotransmission.

Acetycholine is a cholinergic neurotransmitter that ensures transmission of cholinergic nervous signal/synapses at neuromuscular juntion.

Neostigmine inhibiting actions therefore promotes accumulation of acetycholine and thus extended the transmission of cholinergic synapses,

This is expllained the reason why neostigmine mechanisms is used for treatment of neuromuscular disorders e. g autoimmune diseases Myasthenia graviis (weakling of body muscles.

Therfore to counter the advserse effect of Neostigmine;

which include; salvation, head ache, increased muscus secreation, muscle itching, dizziness,

Intravenous application of 0.04mg/kg/dose of atropine sulphate should be given with respect to each dose of Neostigmine administered.

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