The difference between simple diffusion and facilitated diffusion is that facilitated diffusion the difference between simple diffusion and facilitated diffusion is that facilitated diffusion requires atp. moves materials from a higher to a lower concentration. moves materials from a lower to a higher concentration. does not require atp. requires transporter proteins.

- they both deal with molecules that travel down/with a concentration gradient without using energy

- facilitated diffusion uses protein transporters to move substances across a membrane

- the process of simple diffusion occurs only in prokaryotes while facilitated diffusion is seen only in eukaryotes

- simple diffusion doesn't require energy, but facilitated diffusion requires a source of ATP

- simple diffusion can only move material in the direction of a concentration gradient, while facilitated diffusion moves materials with and against a concentration gradient