Do you expect the pI for the sickle-cell β-globin to be higher or lower than the pI for wild-type β-globin? Explain.

Question

Nora Velazquez

Biology

26 February, 23:54

Do you expect the pI for the sickle-cell β-globin to be higher or lower than the pI for wild-type β-globin? Explain.

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Milton · Answer 1

The sickle cell β-globin contains more negative charge than that of wild-type β-globin due to the mutation in HBB gene. The means that it' requires a higher basic level of pH than that of wild-type β-globin to reach it's pI.

So, the sickle cell β-globin has a higher pI than that of wild-type β-globin.