Why can an organ be permanently damaged if its cells are amitotic?

The reason why cells that are amitotic will cause organs to be damaged permanently because cells that are amitotic does not heal or regenerate, causing the organ to be damaged permanently, preventing itself to heal because it does not have a capability of doing it. One example of these cells are called the nerve cells, these cells does not have the capacity to heal itself, causing the person who has damaged these cells to become paralyzed.