Come up with one significant example of artificial selection and not natural selection. Explain why/how it has changed the specifies?

Dog breeding

Explanation:

Humans select traits they desire in pets,

Some of these traits would be selected against by nature:

Ex: Toy breeds have fragile bones, poor health and few defensive capabilities, meaning they are a snack to any predator even small ones like a fox.

Nature wants healthy, strong individuals, in the wild big enough to hunt and strong enough to fight off other predators.