Water is prevented from entering the active site of glycogen phosphorylase. What are the advantages of excluding water from the active site? to prevent the unnecessary breakdown of glycogen to maintain energy supplies in muscle cells to prevent the formation of glucose to prevent energy waste by conserving the ATP ATP that would be needed to phosphorylate glucose to prevent hydrolytic cleavage of glucose 1‑phosphate

Question

Carleigh Molina

Biology

6 January, 01:25

Water is prevented from entering the active site of glycogen phosphorylase. What are the advantages of excluding water from the active site? to prevent the unnecessary breakdown of glycogen to maintain energy supplies in muscle cells to prevent the formation of glucose to prevent energy waste by conserving the ATP ATP that would be needed to phosphorylate glucose to prevent hydrolytic cleavage of glucose 1‑phosphate

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Clarence Wolf · Answer 1

to prevent the formation of glucose,

to maintain energy supplies in muscle cells

to prevent energy waste by conserving the ATP ATP that would be needed to phosphorylate glucose

Explanation:

Glycogenlysis, the breakdown of glycogen involves the activities of glycogen phosphorylase. This enzyme phosphorylated glycogen to glucose-1-phosphate. The latter in presence of enzyme phosphoglucomutase is converted to Glucose-6-phosphate. (GP6)

GP6 enters glycolysis straight, to produce pyruvate. This step has shunted ATPs consumption of the usual glucose phosphoryaltion of the glycolytic pathway, thus conserving more energy for the muscles cells.

However if the glycogen phosphate active site was exposed to water, it will be hydrolyzed to glucose, (instead of glucose-1-phosphate). The glucose will pass through the normal ATPs consuming glycolytic pathways, losing more energy.

Therefore to prevent glucose formation, to conserve energy for immediate availability to ever demanding muscles cells, water is excluded from the active site of glycogen phosphorylase.