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ChemistryChemistry
16 July, 00:02

DNP is referred to as an electron transport chain (ETC) "decoupler," because it uncouples the oxidation of NADH from the synthesis of ATP. In the presence of DNP, NADH is still oxidized by complex I and oxygen can be reduced, but no ATP is produced. Cyanide, a different metabolic poison, inhibits ATP production through a different mechanism - it inhibits the oxidation of complex IV by oxygen. Would you consider cyanide an ETC decoupler?

No, because oxidation of NADH by complex I still occurs in the presence of cyanide.

Yes, because cyanide disrupts the hydrogen ion gradient in mitochondria.

No, because oxidation of NADH is blocked in the presence of cyanide.

Yes, because cyanide inhibits ATP production in mitochondria.

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Answers (1)
  1. 16 July, 00:27
    0
    The correct answer is yes, because cyanide inhibits ATP production in the mitochondria.

    Explanation:

    Uncouplers are the chemical agents which does not have any effect in the transport of electrons through various electron carriers of the electron transport chain but block the formation of ATP.

    Cyanide binds to the complex v also known as ATP synthase and inhibits the functioning of later (ATP synthase). As a result the ATP formation is being blocked.

    Thus cyanide can act as decoupler.
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Home » Chemistry » DNP is referred to as an electron transport chain (ETC) "decoupler," because it uncouples the oxidation of NADH from the synthesis of ATP. In the presence of DNP, NADH is still oxidized by complex I and oxygen can be reduced, but no ATP is produced.
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