If cells in the process of dividing are subjected to colchicine, a drug that interferes with the formation of the spindle apparatus, at which stage will mitosis be arrested?

The question is incomplete as it does not have the options which are:

A) anaphase

B) prophase

C) telophase

D) metaphase

E) interphase

Answer:

The correct answer will be option-D

Explanation:

Colchicine is a drug obtained from the Colchicum autumnale which is a poisonous European flowering plant. The drug is used to treat joint swelling and gout.

Colchicine shows its effect during the cell division cycle especially during the division of nuclear content. When the cell is in metaphase and is preparing for the anaphase, the colchicine inhibits the polymerisation of the microtubules. The inhibition of microtubules inhibits the assembly of the mitotic spindle as a result of this the DNA do not move into new daughter cells.

Thus, option-D is the correct answer.