Consider a protein in which a negatively charged glutamic acid side chain (pKa=4.2) makes a salt bridge (ion-ion interaction) with a positively charged histidine side chain (pKa=6.5).

Part A. Do you predict that this salt bridge will become stronger, become weaker, or be unaffected as pH increases from pH=6.9 to pH=7.5?

Question

Lucia Valentine

Chemistry

22 April, 13:51

Consider a protein in which a negatively charged glutamic acid side chain (pKa=4.2) makes a salt bridge (ion-ion interaction) with a positively charged histidine side chain (pKa=6.5).

Part A. Do you predict that this salt bridge will become stronger, become weaker, or be unaffected as pH increases from pH=6.9 to pH=7.5?

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Answers (1)

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Leonard Riley · Answer 1

The salt bridge will be unaffected by the increase in PH

Explanation:the in introduction of salt bridge in a solution is to maintain a balance between the positive cations and the negatively charge glutamic acid. it does this by releasing positive ion to the glutamic acid solution and releasing negatively charged ions to the histine side of the arrangement. this because over time positive and negatively charged ions may build up at both ends respectively hindering flow of electrons.