Where would you expect to find many hydrophobic amino acids in the 3-D structure of a folded protein that functions in an aqueous solution?

Hydrophobic amino cluster on the inside of the 3-D structure of the folded protein

Explanation:

Hydrophobic interactions, describe the process in which nonpolar, hydrophobic amino acids cluster or aggregate together in the internal part of the protein, to allow the hydrophilic amino acids interact with surrounding water molecules on the outside.