It was found that a reversible inhibitor and a substrate bind an enzyme, but at different sites. The inhibitor was quite potent at reducing enzyme activity, but a Scatchard analysis indicated it could not actually bind the enzyme unless the substrate was bound first. These results led to what conclusion? A. It was a competitive inhibitor. [B [U) B. It was a mixed inhibitor. C. It was an uncompetitive inhibitor. D. It was an allosteric modulator. E. It was a mechanism-based inactivator.

Question

Jazlene Randolph

Chemistry

25 June, 00:36

It was found that a reversible inhibitor and a substrate bind an enzyme, but at different sites. The inhibitor was quite potent at reducing enzyme activity, but a Scatchard analysis indicated it could not actually bind the enzyme unless the substrate was bound first. These results led to what conclusion? A. It was a competitive inhibitor. [B [U) B. It was a mixed inhibitor. C. It was an uncompetitive inhibitor. D. It was an allosteric modulator. E. It was a mechanism-based inactivator.

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Answers (1)

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Cheyanne Kaiser · Answer 1

The correct option is C (Uncompetitive inhibitor)

Explanation:

Uncompetitive inhibitor takes place when an inhibitor binds at different site (allosteric site) of the enzyme after the substrate forms a complex with the enzyme. The Uncompetitive inhibitors bind to a different site on the enzyme while the substrate binds to the active site on the enzyme. It differs from non-competitive inhibition because non-competitive inhibition can occur with or without the presence of the substrate. Uncompetitive inhibition is also referred to as Anti-competitive inhibition.