What alteration to an HCN channel will reduce the transport of K + in favor of Na + transport? HCN channels are permeable to both K + and Na + ions.

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Adelyn Shepherd

Chemistry

1 October, 19:17

What alteration to an HCN channel will reduce the transport of K + in favor of Na + transport? HCN channels are permeable to both K + and Na + ions.

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Samuel Lutz · Answer 1

Decreasing the diameter of the channel by removing aa's. Since Na + is chemically similar to K+, one can assume the difference must be due to the size of the atom. The K + ion is larger than the Na + ion, so reducing the diameter of the channel can allow Na + to enter while preventing K + entry. This explains clearly and perfectly how reducing the diameter reduces the

transport of K + in favor of Na + transport.