Why does perchloric acid cause macromolecules to precipitate?

Perchloric acid (HCO₄) is one of strongest inorganic acids. Perchloric acid precipitation is used to removes most of the protein present in the sample and stabilize many of the small molecule analytes. It can use also to precipitation glycogen, ATP, glutathione, antioxidants.

Perchloric acid donates protons to macromolecules and lower their solubility in water. Also perchloric acid is strong oxidizing agent and change oxidation number of elements.