Hexokinase iv has a km value that is substantially higher than the km for other hexokinases. what is the significance of this fact?

The Km is the MIchealis-Menten constant and this represents the affinity of the enzyme to its substrate. The higher the value for Km, the higher is the affinity of the enzyme to a substrate and the greater is the rate of reaction. Hexokinase IV has a higher Km than other hexokinases because it has a higher affinity to hexose substrates.