Do the number of atoms change in a chemical reaction?

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No.

Explanation:

The reason comes the Law of Conservation of Mass.

In an ordinary chemical reaction, you cannot create or destroy atoms.

So, you must have as many atoms at the beginning of a reaction (in the reactants) as at the end (in the products)

We use this principle to balance chemical equations.

For example, the equation for the formation of water from hydrogen and oxygen is

2H₂ + O₂ ⟶ 2H₂O

There are four atoms of H and two of O both before and after the reaction.