Ask Question
22 December, 15:55

List the following carboxylic acid derivatives in decreasing order of reactivity in nucleophilic acyl substitution reactions: acetic anhydride, methyl acetate, acetamide, acetyl chloride.

+3
Answers (1)
  1. 22 December, 16:03
    0
    acetyl chloride > acetic anhydride > methyl acetate > acetamide

    Explanation:

    Such kind of substitution reaction in which nucleophiles and the acyl compound interact is known as nucleophilic acyl substitution reaction. In this reaction, the interaction between carbonyl compounds and the nucleophile takes place by addition reaction. The reactivity of the acyl compound is based on the condition of the leaving group that is related to the acidity of the compounds. So the decreasing order of reactivity of the acyl compounds is, acetyl chloride > acetic anhydride > methyl acetate > acetamide.
Know the Answer?
Not Sure About the Answer?
Find an answer to your question 👍 “List the following carboxylic acid derivatives in decreasing order of reactivity in nucleophilic acyl substitution reactions: acetic ...” in 📗 Chemistry if the answers seem to be not correct or there’s no answer. Try a smart search to find answers to similar questions.
Search for Other Answers