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2 June, 13:32

For a weak acid such as the side chain ε-amino group of a lysine residue in a protein, if the pKa of that specific residue's ε-amino group is exactly 10.0, in an environment in which the pH = 9.0, what would be the ratio of base to acid?

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  1. 2 June, 13:51
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    0.1

    Explanation:

    Using Henderson-Hasselbalch equation

    pH = pKa + log (base / acid)

    pH = 9.0, pKa = 10.0

    9.0 = 10 + log (base / acid)

    9 - 10 = log (base / acid)

    10⁻¹ = (base / acid)

    (base / acid) = 0.1
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