When should the sponsor-monitor conduct the most detailed review of the study protocol with the site's study staff?

Site initiation visit is the correct answer.

Explanation:

Because the SIV is the sponsor-monitor which administers the detailed analysis of the site's study staff by the study protocol and it observes the process of the visite over a while that it take place after the visite of the site section. It also needed to set up the research site to administrates the analysis. So, that's why the following answer is true.