What might Mary Shelley be saying about human interference with nature?

Thats its dangerous. The consequences are dire and unpredictable. IE the creation of Frankenstein created a creature who questioned its existence, its meaning and place in a natural world where he was everything unnatural. Interference with the natural order of things can bring about great complications and moral dilemas even today, we struggle with the ethics of human cloning and the impact our manmade emissions has on global warming, deforestation etc.