Macbeth and Lady Macbeth are ruined by ambition. To what extent do you agree?

you can talk about how their desire to rule scotland made them blind to what they were losing, relationships with friends and each other and how others percieved them (macbeth went from being a well respected leader). their ambitions towards materialistic things made them lose sight of what really mattered in life, thus leading them down a spiral of doing whatever they could for more power