What is an example of irony in Allen Ginsberg's poem "Howl"?

One of the ironies in the poem 'Howl' was when the writer alludes to to the fact the the best minds of his generation were mad.

Explanation:

An irony is a figure of speech employed by using words whose actual meanings seem opposite in meaning to the intended meaning.

In the poem, 'Howl for Carl Solomon', the writer begins with a lamentation of the best minds in his generation being affected by madness.

This is an irony because an educated and enlightened mind which the author referred to as the best minds in his generation is supposed to be of a sound and logical mind and should not be affected madness, which is an illogical or unreasonable mind.