What advantage did the Spanish have over the Native Americans?

I believe the answer is: Weapons

The soldier from the spanish empire carried guns and canons which considered to be the most advanced weapons at that time. The native american people on the other hand could only rely on Blades, knives, blow darts, and bows to handle the Spanish Soldier.

The Spanish had three major advantages over the Native Americans: guns, germs, and steel. The guns and steel (in the form of swords) decimated thousands of Natives, while the Natives were not immune to the germs many of the Spanish carried.