What are some long term effects of Columbus's journeys

We can think about the outcomes of this voyage in both the short and the long term. In the short term, the voyages led to the destruction of the natives of the lands that Columbus found. Some of them were killed outright. Others were enslaved. Many died of diseases brought by the Europeans. This was the main impact of these voyages in the very short term. Later, Columbus’s voyages led to the domination of the area from Mexico south to Peru by the Spanish. This resulted in the destruction of the major native civilizations like the Incas and the Aztecs. It also resulted in the enrichment and empowerment of Spain.