Why were English colonists so unsuccessful at enslaving Native Americans?

English colonists were unsuccessful at enslaving Native Americans partly due to the fact that Native Americans were less likely to remain in one place for extended periods of time. Additionally, the English were settlers while the Native Americans had lived in the regions for many years and thus were more equipped to fend off English attempts at capturing large groups of people.

The enslavement of Native Americans (when it did occur) was most unsuccessful, though, because Native Americans were not immune to European diseases and thus died at higher rates when in close contact with the English. Citizens in England had been living in crowded cities filled with disease due to poor sanitation for many years prior to colonization and therefore became immune to diseases that Native Americans (who lived in more sanitary conditions) were not accustom to. So when the English would enslave Native Americans, they would become exposed to deadly diseases.