The five most famous American women in all of American history (up to the present), excluding first ladies, are ...

1. Melania Trump. 2. Karen Pence. 3. Lynn Cheney. 4. Abigail Smith adams. 5. Martha wayles skeleton jefferson.

Explanation:

The first lady of the United States is the hostess of the White House. The position is traditionally filled by the wife of the president of the United States, but, on occasion, the title has been applied to women who were not presidents' wives, such as when the president was a bachelor or widower, or when the wife of the president was unable to fulfill the duties of the first lady herself. The first lady is not an elected position; it carries no official duties and receives no salary. Nonetheless, she attends many official ceremonies and functions of state either along with or in place of the president. Traditionally, the first lady does not hold outside employment while occupying the office,[1] although Eleanor Roosevelt earned money writing and giving lectures, but gave most of it to charity.[2] She has her own staff, including the White House social secretary, the chief of staff, the press secretary, the chief floral designer, and the executive chef. The Office of the First Lady is also in charge of all social and ceremonial events of the White House, and is a branch of the Executive Office of the President.