What major historical event in american history depicted the issue of federalism?

The American Civil War from 1861 to 1865 paved the path for the new form of Federalism in the United States, t he Constitution itself created an outline for two types of government being national and state government; the national governments were responsible for security, foreign policy, and commerce, whereas the state governments were predominantly responsible for local laws, economic regulation and criminal law. During the Civil war, conflict arose from whether the States had autonomy over certain laws, this paved the way for the desire to dissolve the Union, however, the union victory solidified the federal government's ultimate power over the States.