How did Jefferson's purchase of the Louisiana Territory actually work against his own vision for America?

President Thomas Jefferson wrote this prediction in an April 1802 letter to Pierre Samuel du Pont amid reports that Spain would retrocede to France the vast territory of Louisiana. As the United States had expanded westward, navigation of the Mississippi River and access to the port of New Orleans had become critical to American commerce, so this transfer of authority was cause for concern. Within a week of his letter to du Pont, Jefferson wrote U. S. Minister to France Robert Livingston: "every eye in the US. is now fixed on this affair of Louisiana. perhaps nothing since the revolutionary war has produced more uneasy sensations through the body of the nation."2