What happened to the Mandan village after the Lewis and Clark expedition? A. They were invaded by American soldiers. B. A fort was established and many were killed by disease. C. They prospered due to trade with the Americans at the fort. D. They left the village and moved farther west.

B. A fort was established and many were killed by disease.

Fort Clark was soon established at the Mandan villages. At first it provided the Mandans with a useful alternative to trading with the British and also offered military support from their traditional native enemies, the Sioux.

However, Americans at the fort unwittingly brought new diseases to the area that decimated the local native population. Where the Mandans had a thriving and sophisticated trading center when Lewis and Clark arrived in 1804, by the late 1830s their total population had been reduced to less than 150.

The nation’s growth combined tragedy and triumph at every turn.

(B) A fort was established and many were killed by disease.

After Lewis and Clark's expedition, the people of mandan village were faced by a devastating outbreak of smallpox disease in the year 1837, as much as the epidemic was devastating it played an important role in uniting the surviving people in Mandan and Hidatsa village who later interacted in trade farming and hunting