What was the most significant cultural change to the Byzantine Empire after the Ottoman's invasion?

The most significant change on the territory of the Byzantine Empire after the Ottoman Turks invaded it, was the change of the religion and the influence of Constantinople as the seat of the Orthodox Christianity. The Ottoman Turks immediately implemented the Islam as a state religion, and they were not fond at all of the Christian faith, so now the situation changed totally, once the empire that promoted Christianity, now became a place for promotion of Islam in the southeastern part of Europe.