How did European exploration impact trade networks and power dynamics in the Eastern Hemisphere?

Several purposes shaped and determined the exploration and development of the transoceanic trade routes Europe undertook, as well as the mastery of new technology and the awareness of new scientific discoveries.

In an effort to reach "The Indies" the clash of civilizations occurred, causing in most cases devastating consequences on the population of the Eastern Hemisphere, and the reorientation of the trade networks (disruption) aslant the Indian and Pacific Oceans.