Why did Jamestown's location cause hardship for the colonists? Its island location was difficult to reach. Its swampy location had a lot of disease. Its coastal location was hit by hurricanes. Its ocean shore location was raided by passing ships.

Its swampy location had a lot of disease

Explanation:

Jamestown was located in a very swampy location with tons of bugs such as mosquitos which usually carry disease. It was muddy and dirty, humid and damp which is the perfect place for disease to grow and spread.