The most serious health problem faced by indigenous populations of the new world in the 16th century was:

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Marcel Navarro

History

20 March, 15:58

The most serious health problem faced by indigenous populations of the new world in the 16th century was:

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Chance · Answer 1

I believe the answer is smallpox, but I could be mistaken. There were lots of viruses threatening the population at the time but from what I know, smallpox was the largest threat.