A major theme present in Renaissance art, but not in Medieval art, is the role of humanism. the role of the Church. the role of agriculture. the role of patrons.

A major theme present in Renaissance art, but not in Medieval art, is the role of humanism.

This is the correct answer simply because there was no Humanism in medieval times - it appeared later, during the era of Renaissance, in the 15th century, when Medieval art was already over. The other options existed both in Renaissance and Medieval art.