A major Renaissance novel about a man who fights imaginary enemies is

A major Renaissance novel about a man who fights imaginary enemies is Don Quixote.

Don Quixote is the correct answer.

Explanation:

Don Quixote is the Spanish novel written by the Miguel de Cervantes. It was published in two parts. It is considered to be the most influential work of the Spanish golden age. It is also labeled as a modern novel. The novel revolves around the adventures of a noble, who after reading chivalric romances loses his mind and tries to become night. He recruits a farmer as his squire.