Although both Sec61 and Sec33 are both involved in secretion, do their localization patterns suggest that they have different roles? Why?

They do have different roles.

Explanation:

A secreted protein begins its process in the Endoplasmic Reticulum then transported to the Golgi. Sec61 is present in the Endoplasmic Reticulum, we can say it's in the Endoplasmic Reticulum a role it is playing in the Endoplasmic Reticulum.

Also, Sec 33 is found in the Golgi, we can also say that Sec 33 has a role in the Golgi.

Sec61 might have a role in relational translocation in the Endoplasmic Reticulum, while Sec 33 a role of maybe processing the protein in the Golgi or transport protein between the Endoplasmic Reticulum and the Golgi.

Hence, since the roles of the Endoplasmic Reticulum and the Golgi are different in secretion so invariably, the roles of Sec 33 and Sec 61 must also be different.