What does the equals sign with the tilted line over it mean?

It means you have to figure out the answer to the question and the answer belongs where the equal sign is

The equals sign like this ≠ or this ≈

≠ basically means does not equal or not equal to.

≈ It's a sign for estimation, like if that answer to an equation was 3.81 and you rounded up to 4 you would put ≈ instead of =