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8 February, 19:24

In mice, an allele for apricot eyes (a) is recessive to an allele for brown eyes (a+). At an independently assorting locus, an allele for tan (t) coat color is recessive to an allele for black (t+) coat color. A mouse that is homozygous for brown eyes and black coat color is crossed with a mouse having apricot eyes and a tan coat. The resulting F1 are intercrossed to produce the F2. In a litter of eight F2 mice, what is the probability that exactly two will have apricot eyes and tan coats? Use three decimal places for the answer.

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  1. 8 February, 19:46
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    The probability that exactly two out of eight mice will have apricot eyes and tan coats is 0.074

    Step-by-step explanation:

    Apricot Eyes = a (Recessive Allele)

    Brown Eyes = a + (Dominant Allele)

    Tan Coat = t (Recessive Allele)

    Black Coat = t + (dominant Allele)

    Homozygous means having only a single type of allele for a trait. The mouse is homozygous for brown eyes (a+a+) and black coat (t+t+) color which means its alleles are a+a+t+t+.

    The mouse with apricot eyes (aa) and tan coat (tt) has an allele set of : aatt

    When a+a+t+t + mouse is crossed with aatt mouse, all of the resulting F1 mice will be having an allele set of aa+tt+.

    Then, two mice having allele set of aa+tt + are crossed to produce F2. The parent set of alleles is a, a+, t, t + and a, a+, t, t+

    The possible allele sets for the eyes can be: a+a+, aa+, a+a, aa

    The possible allele sets for the coat color can be: t+t+, tt+, t+t, tt

    So, the probability of a mouse with apricot eyes and tan coat is:

    P (aa). P (tt)

    From the above listed possible sets of alleles, P (aa) = 1/4 and P (tt) = 1/4

    So, the probability of a mouse having apricot eyes and tan coat is:

    1/4 x 1/4 = 1/16

    To calculate the probability that exactly 2 out of 8 mice will have apricot eyes and tan coat can be calculated using the binomial distribution formula:

    P (X=x) = ⁿCₓ pˣ qⁿ⁻ˣ

    Where p = probability of a mouse having apricot eyes and tan coat

    q = 1-p

    n = total number of mice

    x = number of mice having apricot eyes and tan coat

    We have p = 1/16, q = 15/16, n = 8, x = 2. So,

    P (X=2) = ⁸C₂ (1/16) ² (15/16) ⁶

    = (28) (1/256) (0.6789)

    = 0.074

    The probability that exactly two out of eight mice will have apricot eyes and tan coats is 0.074
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