Aminoglycosides must be used cautiously in children as in adults. dosage must be accurately calculated according to which factors?

The prescription must be precisely calculated conferring to weight and renal function. In addition, evade joining aminoglycosides with potent diuretics in which this upsurges the occurrence of ototoxicity, nephrotoxicity, and neurotoxicity. The renal toxicity in which may develop to renal failure is caused by direct drug harmfulness in the glomerulus, meaning that the drug molecules cause impairment directly to the kidney.