Tay-Sachs is a genetic disorder that destroys nerves and is lethal by age 5. In the Ashkenazi Jewish population, about 1/25 of all individuals are carriers for this recessive disease and are unaware of it. What is the estimated chance of having a child with Tay-Sachs in the Ashkenazi Jewish population?

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1 in 3600 births

Explanation:

Tay-Sachs is the oldest described lipid storage disease. it is a hereditary disorder.

1 in every 30 Ashkenazi Jew carries the defective gene in recessive form.

Although, the disease is rare in population at large, it has high incidence anong Ashkenazi Jews with 1 in 3600 births