Hemoglobin s, the abnormal form of hemoglobin responsible for sickle cell anemia, is the result of a mutation in the gene for the β subunit. this mutation results in the change of

Mutation in the gene of red blood cells results in the change of the shape of red blood cells from circular shape to sickle shape, a sickle shaped red blood cell transports less oxygen as there's a little haemoglobin content in that cell