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12 June, 04:01

Which one of the following enzymes of nucleotide metabolism is correctly paired with its pharmacologic inhibitor?

A. Dihydrofolate reductase-methotrexate

B. Inosine monophosphate dehydrogenase-hydroxyurea

C. Ribonucleotide reductase-5-fluorouracil

D. Thymidylate synthase-allopurinol

E. Xanthine oxidase-probenecid

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Answers (1)
  1. 12 June, 04:03
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    A. Dihydrofolate reductase-methotrexate

    Explanation:

    Dihydrofolate reductase is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid. Methotrexateis its inhibitor. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme.

    Since folateis necassary for rapid dividing cells, such as cancer cells, methotrexate can be used as anticancer drug that inhibits DHFR.
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