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8 November, 12:24

Marfan syndrome can be caused by mutations in either of two genes, but mutations in one of the genes blocks activity of the other. this means that marfan syndrome demonstrates:

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  1. 8 November, 12:44
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    Answer;

    -Genetic heterogeneity and epistasis.

    Explanation;

    -Marfan syndrome is a genetic disorder that affects the body's connective tissue that holds all the body's cells, organs and tissue together.

    -Genetic heterogeneity is defined as mutations at two or more genetic loci that produce the same or similar phenotypes. Genetic heterogeneity may be either; allelic heterogeneity, which occurs when a similar phenotype is produced by different alleles within the same gene; or locus heterogeneity, which occurs when a similar phenotype is produced by mutations at different loci.

    -A gene is said to be epistatic when its presence suppresses the effect of a gene at another locus. Epistatic genes are sometimes called inhibiting genes because of their effect on other genes which are described as hypostatic.

    -From these descriptions the marfan syndrome demonstrates both genetic heterogeneity and epistasis.
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