Insulin preparations are divided into categories based on onset, duration, and intensity of action following subcutaneous inject. Which of the following insulin preparations has the shortest onset and duration of action?

A. Insulin lispro

B. Insulin glulisine

C. Insulin glargine

D. Insulin detemir

A. Insulin lispro

Explanation:

Lispro insulin, also known as ultra-fast acting insulin, has an onset of action of 10 to 15 minutes, the fastest of all insulin types, and its peak duration is approximately one to two hours, being between all, the shorter duration insulin.

The rapid onset of Insulin Lispro activity allows its administration to be closer to a meal (up to 15 minutes before) compared to regular insulin (30 minutes before meal).