Which organs are primarily responsible for removing old or worn red blood cells from circulation?

Liver and spleen is primarily responsible for removing old or worn red blood cells from circulation.

Explanation:

Red blood cells that are old, tear and worn out requires the removal of these cells from the circulation. Spleen removes the old and worn cells by the process of phagocytosis. Macrophages present in the spleen phagocytose the worn RBCs and old RBCs are recycled by the spleen.

Liver also removes the old and worn RBCs from the circulation and recycles iron present in the red blood cells. Liver rely on the buffer system that consume worn RBCs and has the ability of recycling iron.