Some insecticides, such as chlorpyrifos, work by inhibiting the enzyme acetylcholinesterase (AChE), which normally breaks down the neurotransmitter acetylcholine. Where does this insecticide most likely bind to inhibit the enzyme's activity?

Question

Ean Poole

Biology

12 March, 14:54

Some insecticides, such as chlorpyrifos, work by inhibiting the enzyme acetylcholinesterase (AChE), which normally breaks down the neurotransmitter acetylcholine. Where does this insecticide most likely bind to inhibit the enzyme's activity?

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Answers (1)

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Jaydin Duran · Answer 1

Anionic site which binds with the R-N^ + -

Explanation:

The enzyme, acetylcholinesterase is an essential part of the neurone system of both insect and animal. So, care must be taken when organophosphates and cabamates are used as insecticide/pesticide. Acetylcholinesterase contains two main part namely;

(1). Anionic site (negatively charged) : this BINDS with the cationic site of the substrate which is the acetylcholine.

(2). The estaratic site is the site in which primary alcoholic group of the amino acid, serine, attacks the electrophilic part of the subitrage follow by the hydrolysis process in the presence of water which is a very fast reaction. This lead to the regeneration of the enzyme which start the program all over again.