An effect of the voyages of Columbus was that

Columbus and the other European explorers landing in the "new" world caused a massive outbreak of disease due to the lack of acquired immunity held by the native populations in North America.

This biological genocide wiped out a significant amount of the population in the New World making the future conquering of the people relatively easy for the Europeans.

Other nations in Europe worked to profit from the New World as Spain did.

Explanation:

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