Which activity enabled the spread of Minoan civilization from Crete to Greece and other Aegean islands?

The activity that enabled the spread of Minoan civilization was commerce.

Water transport was far more efficient than land transport, and the Mediterranean sea was a major conduit of trade and of contact between cultures.

Minoan civilization, expanded though the establishment of settlements and commercial outposts such as the ones found in Santorini and Kythera from the mid-third millenium BC until the thirteenth century BC.