What made life difficult in Jamestown?

The settlers did not plant their crops in time so they soon had no food. Their leaders lacked the farming and building skills needed to survive on the land. More than half the settlers died during the first winter ... Still, the Jamestown settlers continued to die each year from disease, lack of food and Indian attacks.

The settlers of Jamestown were not equipped for the climate. And had a difficult time in early periods during the winter known as the "starving time". And many did not know how to hunt or do any other forms of labor as they were "second sons". There was also gender imbalance. (extra fact)