Motor neuron degeneration occurs in several diseases and leads to loss of muscle control. One form of motor neuron degeneration was found to have defects in retrograde transport (backward transport to cell body, in blue below) that were caused by mutations in a gene that codes for a particular protein.

What protein, when mutated would inhibit backward, but not outward. transport along axon microtubules? Choose one

A. myosin

B. kinecin

C. dnein

D. tubulin

the correct option is C (dynaina)

Explanation:

Dynaine is a protein found in the neuronal axon, responsible for the retrograde transport of the neuron.

What does this mean? which is responsible for transporting waste, nutrients, metabolites, etc. retrograde in the axon simulating as a kind of carrier.

Therefore, in the absence of this protein or a mutation of it, the neuron will be seriously complicated in terms of its physiology.

In the axon there are two transport routes that go in opposite directions, one is the retrograde route that is in charge of the named protein, and the other is the anterograde.

Movement to the cell body is called retrograde transport, and movement to the synapse is called antegrade transport.

Retrograde transport moves molecules / organelles away from the axon terminal to the cell body.

Answer: C Dynein

Explanation:

Answers A are incorrect since myosin is an ATPase, that is, it hydrolyzes ATP to form ADP and Pi, a reaction that provides muscle contraction, response b is not correct because kinecin is in charge of anterograde transport, and tubulin is a heterodimer component of microtubules but they do not perform retrograde contraction, dynein instead is an almost exclusive mediator of retrograde contraction